Sertoli Hücresi ve Kan-Testis Bariyeri

The Sertoli cell is a critical somatic that initiates the development of testicular morphology and determines important parameters for spermatogenic function. blood-testis barrier, also known as barrier one tightest tissue barriers in mammalian body, an immunological to separate post meiotic germ antigens from systemic circulation. Additionally, creating unique microenvironment spermatocytes exceed into adluminal compartment leptotene stage. It restricts passage substances such paracrine factors, electrolytes, hormones, water, biological molecules apical part seminiferous tubule. separates cells toxic drug-containing environmentally harmful substances, biomolecules This nearly impenetrable prevents proteins, including antibodies, reaching cells. protein leakage developing forming immune response. review explains Sertoli's functional properties, testis barrier's molecular structure, involved dynamics, their importance realizing spermatogenesis.